The building, the origins of which date to the 13th century, was rebuilt in 1424.

The façade, divided into two orders, is embellished by an elegant portal embrasured by fascias of small columns which end in a frescoed lunette (Madonna on the throne between the Saints Francis and Claire). The rose window is of great artistic value for the Church of San Francesco in Cascia.

Today, the Latin-cross interior presents its 15th century structure in the transept and tribune. The nave was magnificently decorated with stucco in 1738. Among the frescoes which remain on the walls and on the choir the following can be distinguished: inside a niche, Madonna with child angels and Saints by Nicola da Siena; Nativity, Trinity and St. Benedict, by Bartolomeo di Tommaso. The canvases include: Madonna, St. Charles and B. Pace, by Antonio Carocci (1658); the Ascension by Niccolo Circignani, so called the Pomarancio (1596), flanked by two canvases attributed to Perino Cesarei (Christ appears to the apostles and Noli me tangere) inside a large wood display case carved by Lorenzo di Giuliano; the Virgin by Paolo Antonio Mattei; Crucified between the angels by Ercole Orfei from Fano (1579).